A 2022 avian H5N1 influenza A virus from clade 2.3.4.4b attaches to and replicates better in human respiratory epithelium than a 2005 H5N1 virus from clade 2.3.2.1
Lisa Bauer, Lonneke M. E. Leijten, Matteo Iervolino, Varun Chopra, Laura van Dijk, Mark Power, Willemijn F. Rijnink, Mark Pronk, Monique I. J. Spronken, Mathis Funk, Rory D. de Vries, Mathilde Richard, Thijs Kuiken, Debby A.J. van Riel
This study compares the attachment and replication efficiency of a 2022 H5N1 avian influenza virus with a 2005 strain in human respiratory epithelium, finding the 2022 virus replicates more efficiently.
The Lancet Microbe · Dec 15, 2025Peer-reviewedMicrobiology