Mathilde Richard

This paper introduces a high-throughput pipeline for selective mutational scanning in influenza viruses, enabling rapid assessment of variant fitness and escape potential.

This study shows that 3D tonsil cultures with stromal cells enhance antigen-specific B cell responses compared to 2D cultures and improve follicle-like structure formation.

This study identifies transient RNA structures that drive nucleotide insertions leading to the formation of MBCSs in HPAIVs.

This study identifies that H5Nx influenza A viruses bind promiscuously to avian-type mucin-like O-glycans, enhancing their zoonotic potential by binding human tracheal tissues.

This study compares the attachment and replication efficiency of a 2022 H5N1 avian influenza virus with a 2005 strain in human respiratory epithelium, finding the 2022 virus replicates more efficiently.

The paper creates a high-resolution antigenic map of A(H5) HA and uses it to design vaccine antigens that confer broad immunity against diverse A(H5) viruses.

The paper shows that a single Q226L mutation in the HA protein of a 2.3.4.4e H5 virus allows it to bind human-type receptors, unlike a modified 2.3.4.4b virus.