FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity
Erik Ladewig, Abbas Nazir, Tyler Park, Vinson B. Fan, Zhendong Cao, Jacob Hawk, Lauren Kelly, Robert Tjian, Christina S. Leslie, Charles L. Sawyers
This study identifies FOXA1 mutations in prostate cancer, showing they alter chromatin accessibility and promote tumorigenicity by reprogramming cell fate through interactions with androgen receptor and POU2F1.
Cell Reports · Jan 31, 2026Peer-reviewedGenomics