Genetic and pharmacologic alterations of claudin9 levels suffice to induce functional and mature inner hair cells
Yingying Chen, Jeong Han Lee, Jin Li, Seojin Park, Maria Cristina Perez Flores, Braulio Peguero, Jennifer Kersigo, Mincheol Kang, Jinsil Choi, Lauren Levine, Michael Anne Gratton, Bernd Fritzsch, Ebenezer N. Yamoah
This study shows reducing Cldn9 levels pharmacogenetically generates functional inner hair cells in mice, which are durable and resemble normal cells.
bioRxiv · Oct 8, 2023 · PreprintNeuroscience