Jin Li

Mechanosensitive Endothelial METTL7A Regulates Internal m7G mRNA Methylation and Protects Against Atherosclerosis

This study identifies METTL7A as a mechanosensitive methyltransferase that regulates internal m7G methylation in endothelial cells, protecting against atherosclerosis through stabilization of anti-inflammatory transcripts.

An Integrated Multi-omics Single Cell Atlas of the Human RPE and Choroid

The paper constructs a multi-omics single-cell atlas of human RPE and choroid, identifying cell types, aging patterns, and genetic risk factors for AMD.

An oncolytic adenovirus armed with anticancer prodrug-activating enzyme offers enhanced tumor killing and antitumor immunity.

This study develops an oncolytic adenovirus that activates a prodrug to enhance tumor killing and antitumor immunity through direct oncolysis, bystander effects, and systemic immune responses.

Functional specialization and dynamical interaction in human amygdala subregions support fearful-expression recognition

This study identifies distinct functional roles of human amygdala subregions in fearful-expression recognition through intracranial EEG and stimulation, revealing bidirectional interactions and a temporal hierarchy.

Pln1 Mediates Lipid Droplet-Vacuole Tethering During Microlipophagy Saccharomyces cerevisiae

This study identifies Pln1 as a mediator of lipid droplet-vacuole tethering during microlipophagy in Saccharomyces cerevisiae, revealing its role in LD degradation and survival under starvation.

Neuro-Immune Communication at the Core of Craving-Associated Brain Structural Network Reconfiguration in Methamphetamine Users

This study investigates structural brain network changes in methamphetamine users during long-term abstinence and links them to craving mechanisms using network control theory and multimodal analyses.

Limitations in PPAR-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells

This study identifies PPAR-dependent mitochondrial programming as a limiting factor in the differentiation of human stem cell-derived β cells and shows that PPAR agonists can enhance β cell formation and function.

Coronary Artery Disease risk variant dampens the expression of CALCRL by reducing HSF binding to shear stress responsive enhancer in endothelial cells

The paper identifies a CAD risk SNP rs880890 in an endothelial enhancer that reduces CALCRL expression by impairing HSF binding under shear stress.

Spatial transcriptomics and single-nucleus RNA sequencing reveal a transcriptomic atlas of adult human spinal cord

The paper uses single-nucleus RNA sequencing and spatial transcriptomics to classify adult human spinal cord neurons into 21 subclusters and compare them with mouse data, revealing similarities and sex differences.

Increased FAN1 expression by mRNA-LNP attenuates CAG repeat expansion in Huntington patients' iPSC-derived astrocytes

The paper shows that increasing FAN1 expression in HD patient astrocytes reduces CAG repeat expansion using mRNA-LNP.

Genetic and pharmacologic alterations of claudin9 levels suffice to induce functional and mature inner hair cells

This study shows reducing Cldn9 levels pharmacogenetically generates functional inner hair cells in mice, which are durable and resemble normal cells.

Single-nucleus transcriptomic atlas of spinal cord neuron in human

This study generates the first comprehensive single-nucleus RNA-seq atlas of human spinal cord neurons, identifying 18 clusters and novel marker genes, and comparing them to mouse data.

Genome wide association analysis in dilated cardiomyopathy reveals two new key players in systolic heart failure on chromosome 3p25.1 and 22q11.23

This study performs a large GWAS on dilated cardiomyopathy, identifying two new loci and confirming two existing ones, with potential therapeutic implications.

LiBis: An ultrasensitive alignment method for low-input bisulfite sequencing

LiBis improves low-input bisulfite sequencing by increasing mapping ratio and informative CpGs for better methylation analysis in liquid biopsies.

Integrated analysis of a compendium of RNA-Seq datasets for splicing factors

The paper integrates RNA-Seq datasets to identify key splicing factors in diseases and biological processes using signature comparison analysis.

brt: An R package for integrating biological relevance with p value in omics data

The paper introduces a new statistical method, BRT, to assess biological relevance in omics data by incorporating effect size with p-values, and demonstrates its application on microarray data.

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

The paper identifies genetic variants and transcripts associated with glycemic traits by analyzing exome-array data from 144,600 individuals, highlighting tissue-specific roles in glucose regulation.

Genome-wide transcriptome analysis identifies alternative splicing regulatory network and key splicing factors in mouse and human psoriasis

CITGeneDB: A comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice

CITGeneDB curates human and mouse genes that enhance or suppress cold-induced thermogenesis through perturbation experiments in mice, providing a searchable database for research on obesity and diabetes.