Epg5 links proteotoxic stress due to defective autophagic clearance and epileptogenesis in Drosophila and Vici Syndrome patients
Celine Deneubourg, Hormos Salimi Dafsari, Simon A. Lowe, Aitana Martinez-Cotrina, David Mazaud, Seo Hyun Park, Virginia Vergani, Reza Maroofian, Luisa Averdunk, Ehsan Ghayoor Karimiani, Sandeep Jayawant, Cyril Mignot, Boris Keren, Renate Peters, Arveen Kamath, , Manolis Fanto
This study links proteotoxic stress from defective autophagy to epileptogenesis in Drosophila and Vici Syndrome patients, suggesting autophagy-stimulating diets as a potential treatment.
bioRxiv · Apr 23, 2024 · PreprintNeuroscience