Simon A. Lowe

This study shows that nighttime sleep in Drosophila is necessary for mechanosensory habituation, likely by promoting synaptic downscaling.

This study shows that micro- and nano-plastics worsen Parkinson's Disease-like symptoms in a fruit fly model with mitochondrial defects.

The paper identifies biallelic variants in ARHGAP19 as a cause of motor-predominant neuropathy with conduction slowing in multiple families.

This study links proteotoxic stress from defective autophagy to epileptogenesis in Drosophila and Vici Syndrome patients, suggesting autophagy-stimulating diets as a potential treatment.

This study shows that gain-of-function BK channel mutations disrupt limb control in fruit flies by altering neuronal development during a critical period, not by affecting mature circuits.

This study creates a Drosophila model with a hSlo1 D434G mutation, showing motor dysfunction and altered action potentials linked to BK channel gain-of-function.

This study examines how a BK channel mutation affects synaptic plasticity and motor circuits in Drosophila larvae, finding altered neurotransmitter release and CPG dysfunction.

This study shows that overexpressing the Drosophila DYRK1A ortholog, minibrain, in neurons leads to motor decline, neurodegeneration, and synaptic changes similar to Down syndrome features.

This study investigates how mutations in Membrin/GOSR2 affect dendritic growth and synaptic integrity in Drosophila models, revealing their role in neurological disorders.