Development and validation of polygenic scores for within-family prediction of disease risks
Spencer Moore, Ivan Davidson, Jonathan Anomaly, Jeremiah H. Li, Mohammad Mehdi Ahangari, Lauren Moissiy, Michael Christensen, Alexander I. Young, David Stern, Tobias Wolfram
This paper develops and validates polygenic scores for within-family disease risk prediction, showing strong performance across ancestries and demonstrating their clinical utility in embryo screening.
medRxiv · Aug 6, 2025 · PreprintGenetic & Genomic Medicine