Tobias Wolfram

This paper improves depression prediction by integrating psychiatric traits, showing stronger associations across development, families, and populations.

The paper assesses the association between rare variant genetic loads and cognitive traits, intellectual disability, and psychiatric disorders in population-based cohorts.

This paper proposes using embryo-level autozygosity as a biomarker to prioritize embryos with lower disease risk in preimplantation genetic testing for couples with consanguinity.

ImputePGTA improves embryo genotyping and polygenic scoring from ultra-low-pass sequencing by jointly inferring inheritance and parental haplotype phasing.

This study develops and evaluates HLA-ARC, a polygenic risk score for type 1 diabetes, showing improved performance over existing methods in diverse ancestry groups.

This paper develops and validates polygenic scores for within-family disease risk prediction, showing strong performance across ancestries and demonstrating their clinical utility in embryo screening.

This GWAS identifies 106 genetic variants associated with occupational status and shows genetic and environmental factors contribute to intergenerational status transmission and health outcomes.