Ivan Davidson

This paper proposes using embryo-level autozygosity as a biomarker to prioritize embryos with lower disease risk in preimplantation genetic testing for couples with consanguinity.

ImputePGTA improves embryo genotyping and polygenic scoring from ultra-low-pass sequencing by jointly inferring inheritance and parental haplotype phasing.

This study develops and evaluates HLA-ARC, a polygenic risk score for type 1 diabetes, showing improved performance over existing methods in diverse ancestry groups.

This paper develops and validates polygenic scores for within-family disease risk prediction, showing strong performance across ancestries and demonstrating their clinical utility in embryo screening.