Microglia-specific NF-κB signaling is a critical regulator of prion-induced glial inflammation and neuronal loss
Arielle J. D. Hay, Katriana A. Popichak, Genova Mumford, Payton M. Shirley, Jifeng Bian, Lauren Wolfrath, Samantha Lei, Michael Eggers, Eric M. Nicholson, Ronald B. Tjalkens, Mark D. Zabel, Julie A. Moreno
This study shows that microglial NF-κB signaling is critical for prion disease progression, with IKK KO microglia leading to faster disease onset and neuronal loss.
PLoS Pathogens · Jun 18, 2025Peer-reviewedMolecular Biology