PET imaging of an antisense oligonucleotide in the living non-human primate brain using click chemistry
Brendon E. Cook, Thomas C. Pickel, Sangram Nag, Philippe N. Bolduc, Rouaa Beshr, Anton Forsberg Morén, Cathy A. Muste, Giulia Boscutti, Di Maria Jiang, Long Yuan, Prodip Datta, Piotr Ochniewicz, Yasir Khani Meynaq, Sac-Pham Tang, Christophe Plisson, , Maciej A. Kaliszczak
This paper demonstrates a pretargeted PET imaging method to visualize antisense oligonucleotide distribution in non-human primate brains after intrathecal delivery.
bioRxiv · Feb 6, 2025 · PreprintNeuroscience