Christer Halldin

This study evaluates how temperature affects UCB-1A binding to SV2A and SV2C using experimental assays and molecular dynamics simulations, finding that binding to SV2C remains stable while SV2A shows temperature sensitivity.

This paper develops UCB-1A, the first PET radioligand for imaging SV2C, showing it binds selectively to SV2C in brain regions and is suitable for Parkinson's disease studies.

This paper demonstrates a pretargeted PET imaging method to visualize antisense oligonucleotide distribution in non-human primate brains after intrathecal delivery.

This study identifies a GGC expansion in the ZFHX3 gene as the cause of SCA4, associated with dysautonomia and motor neuron signs.

This study evaluates the validity and reliability of [11C]raclopride PET for quantifying D2/3R binding outside the striatum, finding it unreliable in extrastriatal regions.

This study evaluates the accuracy and reliability of specific binding estimates for [11C]PBR28 using the SIME method, showing good precision and reliability for VS but variability in BPND.

This study attempts to replicate previous findings linking dopamine D1 receptor availability to social behavior using PET and personality scales but finds no significant correlations.