Sangram Nag

This study evaluates [18F]UCB-F as a PET radioligand for imaging SV2C, finding it unsuitable due to poor in vivo stability and brain retention.

This study evaluates how temperature affects UCB-1A binding to SV2A and SV2C using experimental assays and molecular dynamics simulations, finding that binding to SV2C remains stable while SV2A shows temperature sensitivity.

This paper develops UCB-1A, the first PET radioligand for imaging SV2C, showing it binds selectively to SV2C in brain regions and is suitable for Parkinson's disease studies.

This paper demonstrates a pretargeted PET imaging method to visualize antisense oligonucleotide distribution in non-human primate brains after intrathecal delivery.