Cholinergic basal forebrain degeneration due to obstructive sleep apnoeaincreases Alzheimer's pathology in mice
Lei Qian, Leda Kasas, Michael Milne, Oliver Rawashdeh, Nicola Marks, Aanchal Sharma, Mark C. Bellingham, Elizabeth Jane Coulson
This study shows that inducing obstructive sleep apnoea in a mouse model of Alzheimer's disease increases Alzheimer's pathology, including amyloid-beta and inflammatory markers, through mechanisms involving hypoxia and the p75 neurotrophin receptor.
bioRxiv · Mar 12, 2020 · PreprintNeuroscience