Elizabeth Jane Coulson

The paper shows that cholinergic basal forebrain neurons influence vascular-CSF coupling and glymphatic flux in mice, suggesting a neurovascular mechanism for waste clearance in the brain.

This study shows that activating the M4 muscarinic receptor in quiescent neural precursor cells enhances adult hippocampal neurogenesis and rescues impairments caused by cholinergic neuron loss.

The paper develops and validates a quantitative method using sodium fluorescein to assess BBB and BSCB integrity in neurodegenerative disease models, showing increased permeability in specific disease models.

This study shows that inducing obstructive sleep apnoea in a mouse model of Alzheimer's disease increases Alzheimer's pathology, including amyloid-beta and inflammatory markers, through mechanisms involving hypoxia and the p75 neurotrophin receptor.