Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutieres Syndrome neuropathology
Kelsey Marie Nemec, Genevieve Gucci Grace Capispisan Uy, V Sai Chaluvadi, Freddy S Purnell, Bilal Elfayoumi, Leila Byerly, Micaela L O'Reilly, Carleigh A O'Brien, William H. Aisenberg, Sonia I Lombroso, Xinfeng Guo, Niklas Blank, Chet Huan Oon, Fazeela Yaqoob, Brian Temsamrit, , F. Chris Bennett
This study introduces ER-Hoxb8 macrophages as a model for microglia replacement and uses them to study the role of Adar1 mutations in Aicardi-Goutieres Syndrome.
eLife · Jan 27, 2026Peer-reviewedNeuroscience