Author

Carleigh A O'Brien

University of PennsylvaniaORCID 0000-0003-4549-0640Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

F. Chris BennettiD· 2 shared Kelsey Marie NemeciD· 2 shared Aaron J. LongworthiD· 1 shared Adam P. WilliamsoniD· 1 shared Alexander Z Zhang· 1 shared Bilal Elfayoumi· 1 shared Brian Temsamrit· 1 shared Caterina P. ProfaciiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

F. Chris BennettORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

NeuroscienceeLifePeer-reviewedJan 27, 2026

Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutieres Syndrome neuropathology

Kelsey Marie Nemec, Genevieve Gucci Grace Capispisan Uy, V Sai Chaluvadi…·F. Chris Bennett

This study introduces ER-Hoxb8 macrophages as a model for microglia replacement and uses them to study the role of Adar1 mutations in Aicardi-Goutieres Syndrome.

3 citations

mouseexperimental assay

𝕏 PostBluesky

NeuroscienceNeuronPeer-reviewedAug 13, 2024

Microglia are not required for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism

Caterina P. Profaci, Sean S. Harvey, Kaja Bajc…·Richard Daneman

The paper investigates the role of microglia in maintaining blood-brain barrier properties in health and finds that microglia are not required, but PLX5622 treatment affects endothelial cholesterol metabolism.

55 citationstop 1%

mousebulk RNA-seq

𝕏 PostBluesky