Chet Huan Oon

This study introduces ER-Hoxb8 macrophages as a model for microglia replacement and uses them to study the role of Adar1 mutations in Aicardi-Goutieres Syndrome.

The paper identifies loss of stromal KITL as a mechanism promoting tumor progression in the pancreas by disrupting tissue homeostasis.

The paper shows EGFR is required for Wnt9a-Fzd9b signaling specificity in HSPC development, identifying key domains and phosphorylation events.