Characterization of sequence specific binding of LARP6 to the 5' stem-loop of type I collagen mRNAs and implications for rational design of antifibrotic drugs
Lela Stefanovic, Blaine H. Gordon, Robert Silvers, Branko Stefanovic
This study identifies the RNK motif in LARP6's La-domain as critical for sequence-specific binding to the 5SL of collagen mRNAs, suggesting it as a target for antifibrotic drug design.
bioRxiv · Sep 30, 2020Molecular Biology