Robert Silvers

The paper determines the molecular structures of RiboGreen, OliGreen, and PicoGreen using NMR and mass spectrometry, revealing their cyanine structure and binding mechanisms to nucleic acids.

This study shows gangliosides GM3 and GD3 accelerate insulin aggregation into non-fibrillar structures that are less toxic than fibrillar aggregates, suggesting potential therapeutic implications for Type-2 Diabetes.

This paper reconstructs extinct glucokinase (GCK) and glucokinase regulatory protein (GKRP) to study the evolutionary origins of protein regulation in vertebrate glucose homeostasis.

This paper investigates how aducanumab binds to Aβ1-42 fibrils, showing it preserves the fibril core structure while altering N-terminal dynamics and reducing secondary nucleation.

This paper presents the NMR structure of HsLARP6's La domain bound to a 5' stem-loop RNA, revealing a non-canonical binding interface that enables specific recognition of structured RNA.

This paper describes a protocol to produce and purify the La domain of human LARP6, showing that RNA binding increases its stability and reduces aggregation.

This study identifies the RNK motif in LARP6's La-domain as critical for sequence-specific binding to the 5SL of collagen mRNAs, suggesting it as a target for antifibrotic drug design.