SARM1, the executioner of axon degeneration, is an ADP-ribosyl transferase and autoMARylation negatively regulates its activation
Janneke D. Icso, Leo DeOrsey, Leonard Barasa, Brian A. Kelch, Paul R. Thompson
This study identifies SARM1 as an ADP-ribosyl transferase that auto-MARylates, regulating its activity and subcellular localization in axon degeneration.
bioRxiv · Sep 12, 2025 · PreprintBiochemistry