Paul R. Thompson

This study shows that PAD2 knockout reduces protein citrullination, improves motor neuron and axon integrity, and modulates neuroinflammation in a SOD1-ALS mouse model.

This study shows PADs and mSWI/SNF chromatin remodelers reciprocally regulate each other's expression and function in skeletal muscle differentiation and regeneration.

This study identifies SARM1 as an ADP-ribosyl transferase that auto-MARylates, regulating its activity and subcellular localization in axon degeneration.

This paper develops a fluorogenic substrate for Chikungunya virus protease (nsP2) that improves signal-to-noise ratio and specificity for inhibitor screening.

This study screens over 30,000 compounds to identify new anthelmintics effective against gastrointestinal nematodes, finding 55 compounds with broad-spectrum activity.

This study shows that Pkm2 and Pkm1 regulate chromatin remodeling and histone phosphorylation during myoblast differentiation by affecting mSWI/SNF subunits and histone modifications.