Author

Leo Tianlai Chen

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:benchmark study· 1 Research Focus:benchmarking· 1 Approach:contrastive learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:proteomics· 1

Frequent Co-Authors

Debora S. MarksiD· 1 shared George McDonald ChurchiD· 1 shared Melissa Du· 1 shared Pranam ChatterjeeiD· 1 shared Pranay Vure· 1 shared Rishab PulugurtaiD· 1 shared Rohit Krishan Arora· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 9 mutual co-author links

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1 shared paperBioinformatics

Debora S. MarksORCID

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Author profile →

2 papers

Recent·Most cited

PG-LLM: Benchmarking General-Purpose Language Models for Protein Variant Ranking

Rohit Krishan Arora, Leo Tianlai Chen, Melissa Du, Debora S. Marks, George McDonald Church

PG-LLM benchmarks language models for protein variant ranking, showing they outperform many sequence-based predictors but fall short of specialized models.

bioRxiv · Aug 21, 2026 · PreprintBioinformatics

DPAC: Prediction and Design of Protein-DNA Interactions via Sequence-Based Contrastive Learning

Leo Tianlai Chen, Rishab Pulugurta, Pranay Vure, Pranam Chatterjee

DPAC predicts and designs protein-DNA interactions using sequence-based contrastive learning, outperforming structure-based methods in speed and accuracy.

bioRxiv · May 14, 2025 · PreprintBioengineering