Moving Beyond Binary Biomarkers: Machine Learning Model Resolves Concurrent and Molecularly Heterogeneous Mismatch Repair and Homologous Recombination Deficiencies in Prostate Cancer
Komal Sharma, Divin A. Wilson, Yu Wang, Shabi Haider, Vineel Bhatlapenumarthi, Daniel Boiarsky, John M. Cipriaso, Leo Yermakov, Raja Ram Dutta, Manavita Vashisth, Ilsa M. Coleman, Armand Bankhead, Shantanu K. Jadhav, Bhabishya Neupane, Bradley W. Taylor, , Navonil De Sarkar
This paper develops a machine learning model to identify molecularly distinct DDR subgroups in prostate cancer, revealing concurrent repair deficiencies and improving therapeutic stratification.
bioRxiv · Oct 8, 2025 · PreprintGenomics