Deletion or Targeted Blockade of FcγRIIb (CD32b) Impairs α-Syn Propagation In-Vivo
James M. Hennegan, Michael J. Hurley, Kerry L. Cox, Leon R. Douglas, Patrick J. Duriez, Robert J. Oldham, Mark Steven Cragg, Björn Frendéus, Ali Roghanian, Jessica L. Teeling
This study shows that FcγRIIb promotes α-syn propagation and neurotoxicity in vivo, suggesting it as a therapeutic target for synucleinopathies.
bioRxiv · Nov 18, 2025 · PreprintNeuroscience