Author

Leonard Christian

Medizinische Hochschule Hannover

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Bioinformatics· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Organism:human· 5 Approach:statistical model· 4 Approach:experimental assay· 3 Assay:spatial transcriptomics· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Jonas C. SchuppiD· 5 shared Jan C. KampiD· 4 shared Lavinia NeubertiD· 4 shared Naftali KaminskiiD· 4 shared Christine Susanne FalkiD· 3 shared Danny David JonigkiD· 3 shared Fabio IusiD· 3 shared Hande Yilmaz· 3 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCell Biology

Jonas C. SchuppORCID

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5 papers

Recent·Most cited

Single-cell and spatial transcriptomics resolve airway obliteration in bronchiolitis obliterans syndrome

Jannik Ruwisch, Hande Yilmaz, Leonard Christian, Lavinia Neubert, Lena Maureen Leiber, Annalea Brüggemann, Sneha Banerjee, Mark Greer, Wiebke Rackwitz, Leon Giercke, Christopher Werlein, C.A. Pawlow, Regina Engelhardt, Axelle Coppens, Matthias Ballmaier, , Jonas C. Schupp

This study uses single-cell and spatial transcriptomics to identify structural cell circuits in BOS lungs and their spatial organization during airway obliteration.

bioRxiv · Aug 23, 2026 · PreprintCell Biology

Aberrant and Ectopic Cell Populations of the Fibrotic Pushing Border in Restrictive Allograft Syndrome after Lung Transplantation

Lena Maureen Leiber, Leonard Christian, Lavinia Neubert, Jannik Ruwisch, Hande Yilmaz, Edith Katharina Plucinski, Linus Langer, Jan C. Kamp, Mark Greer, Bernd Haermeyer, Kühnel Mark, Christopher Werlein, A. Justet, Anke K. Bergmann, Hanne Beeckmans, , Jonas C. Schupp

This study identifies aberrant cell populations in RAS lungs using snRNA-seq and histology, revealing a fibrotic niche composed of specific cell types with potential therapeutic targets.

European Respiratory Journal · Jul 9, 2026Peer-reviewedCell Biology

Clonal Hematopoiesis Instructs Maladaptive Tissue Repair to Promote Fibrosis

Dongzhu Li, Ana C. Viñado, Paula García‐Olloqui, Sydney B. Montesi, Barry S. Shea, Leonard Christian, Iria Vázquez-Urio, Paula Aguirre-Ruiz, Beñat Ariceta, Manuela Neubert, Ashutosh Tripathy, Niloy Barua, Pablo Valera, Laura Vera, Eva Petri, , Ana Pardo–Saganta

This study shows clonal hematopoiesis promotes fibrosis by altering macrophage behavior and tissue repair processes in lung disease.

bioRxiv · Mar 26, 2026 · PreprintImmunology

Spatial transcriptomics uncovers hybrid, pro-inflammatory and pro-fibrotic cellular niches in pulmonary granuloma of patients with chronic sarcoidosis

Leonard Christian, Hande Yilmaz, Jannik Ruwisch, Leon Giercke, Benjamin Seeliger, Jan C. Kamp, Sirvan Bayraktar, Raphael Ewen, Theresa Graalmann, Jan Fuge, Mark Greer, Fabio Ius, Tobias Welte, Shu‐Yi Liao, Ivana V Yang, , Jonas C. Schupp

This study uses spatial transcriptomics to identify hybrid pro-inflammatory and pro-fibrotic cellular niches in sarcoidosis granulomas, linking them to fibrosis and immune responses.

American Journal of Respiratory and Critical Care Medicine · Jan 5, 2026Peer-reviewedMolecular Biology

A multicenter spatial transcriptomics atlas of human tuberculosis and non-tuberculous mycobacterial disease

Xun Jiang, Leonard Christian, Yuesi Xi, Liang Zhou, Ahmed Alaswad, Xiaoyi Zheng, Nienke van Unen, Lavinia Neubert, Jana Dietrich, Jan C. Kamp, Moritz Z. Kayser, Mark Kühnel, Jens Michael Hohlfeld, Hortense Slevogt, Marius M. Hoeper, , Yang Li

This study creates a spatial transcriptomics atlas of human tuberculosis and non-tuberculous mycobacterial granulomas, identifying distinct niches and immune signatures.

bioRxiv · Oct 17, 2025 · PreprintBioinformatics