Spatial transcriptomics uncovers hybrid, pro-inflammatory and pro-fibrotic cellular niches in pulmonary granuloma of patients with chronic sarcoidosis
Leonard Christian, Hande Yilmaz, Jannik Ruwisch, Leon Giercke, Benjamin Seeliger, Jan C. Kamp, Sirvan Bayraktar, Raphael Ewen, Theresa Graalmann, Jan Fuge, Mark Greer, Fabio Ius, Tobias Welte, Shu‐Yi Liao, Ivana V Yang, , Jonas C. Schupp
This study uses spatial transcriptomics to identify hybrid pro-inflammatory and pro-fibrotic cellular niches in sarcoidosis granulomas, linking them to fibrosis and immune responses.
American Journal of Respiratory and Critical Care Medicine · Jan 5, 2026Peer-reviewedMolecular Biology