Ruxolitinib clears CRYAB p.Arg120Gly aggregates through the ubiquitin-proteasome system
Erda Alizoti, Leonie Ewald, Simona Parretta, Moritz Meyer-Jens, Ellen Orthey, Christian Conze, Lucie Carrier, Jeffrey M. Robbins, Sonia R. Singh
This study shows ruxolitinib reduces CRYAB p.Arg120Gly protein aggregates in DRM models by enhancing the ubiquitin-proteasome system.
bioRxiv · Oct 11, 2024 · PreprintPharmacology & Toxicology