Christian Conze

Carbenoxolone blocks cell migration by inhibiting SERCA, causing ER Ca2+ leak and disrupting intracellular Ca2+ homeostasis.

This study shows hydrogen peroxide modulates axonal microtubule dynamics and induces distinct phosphorylation patterns in microtubule proteins through specific signaling pathways.

This study shows ruxolitinib reduces CRYAB p.Arg120Gly protein aggregates in DRM models by enhancing the ubiquitin-proteasome system.

This study identifies podocyte exopher-formation as a novel mechanism for removing antigen/autoantibody aggregates in membranous nephropathy, with potential for non-invasive monitoring.

The paper uses live-cell imaging to identify a drug candidate that restores microtubule regulation by targeting tau aggregation and phosphorylation in a tauopathy model.

This study shows that tau and α-synuclein regulate microtubule organization and transport in neuronal dendrites, with tau deficiency increasing dendritic complexity and transport efficiency.