Author

Lesia Szyca

Ontario Institute for Cancer Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Christopher M. LalansinghiD· 2 shared Stephenie D. ProkopeciD· 2 shared Anthony Charles NicholsiD· 1 shared Cindy Q. Yao· 1 shared Constance H. LiiD· 1 shared David H. Park· 1 shared Fan FaniD· 1 shared Fouad Yousif· 1 shared

Activity by Year

2018-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBioinformatics

Christopher M. LalansinghORCID

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2 papers

Recent·Most cited

Accurate Reference-Free Somatic Variant-Calling by Integrating Genomic, Sequencing and Population Data

Ren Sun, Christopher M. Lalansingh, Shadrielle M. G. Espiritu, Cindy Q. Yao, Takafumi N. Yamaguchi, Stephenie D. Prokopec, Lesia Szyca, Kathleen E. Houlahan, Lawrence E. Heisler, Morgan D Black, Constance H. Li, John W. Barrett, Anthony Charles Nichols, Paul Christopher Boutros

S22S is a reference-free method for somatic variant calling that uses genomic and population data to accurately identify SNVs without matched normal samples.

bioRxiv · Aug 2, 2018 · PreprintBioinformatics

The Origins and Consequences of Localized and Global Somatic Hypermutation

Fouad Yousif, Stephenie D. Prokopec, Ren X. Sun, Fan Fan, Christopher M. Lalansingh, David H. Park, Lesia Szyca, PCAWG Network, Paul C. Boutros

This study identifies genes driving localized and global hypermutation in tumors and finds that kataegis (localized mutation rainstorms) are associated with specific genetic alterations and patient outcomes.

bioRxiv · Jun 29, 2018 · PreprintCancer Biology