Lawrence E. Heisler

The Landscape of Prostate Tumour Methylation

This study maps epigenomic heterogeneity in prostate cancer by analyzing 3,001 methylomes and identifies four subtypes with distinct clinical and molecular features.

The Telomere Length Landscape of Prostate Cancer

This study examines telomere length in prostate cancer, finding associations with genomic instability and clinical outcomes.

The Paf1 complex broadly impacts the transcriptome of Saccharomyces cerevisiae

This study investigates the role of the Paf1 complex in regulating the transcriptome of Saccharomyces cerevisiae, revealing its impact on both coding and noncoding transcripts through transcriptional and post-transcriptional mechanisms.

Accurate Reference-Free Somatic Variant-Calling by Integrating Genomic, Sequencing and Population Data

S22S is a reference-free method for somatic variant calling that uses genomic and population data to accurately identify SNVs without matched normal samples.

A comprehensive multicenter comparison of whole genome sequencing pipelines using a uniform tumor-normal sample pair

This study compares whole genome sequencing pipelines across five centers using a uniform tumor-normal sample pair, identifying factors affecting output consistency.