Wearable sweat nicotine biosensor based on a nicotineoxidoreductase and its natural electron acceptor
Zhehao Zhang, Abdurrahman Addokhi, Kristin A. Hughes, Hao Zang, Maria Del Carmen Piqueras, Uroš Kuzmanović, Roger Charles, Leslie Leung, Catherine M. Klapperich, Karen N. Allen, Mark W. Grinstaff, James E. Galagan
This paper develops a wearable nicotine biosensor using NicA2 and CycN, achieving high sensitivity and selectivity for real-time sweat monitoring.
bioRxiv · Oct 31, 2025 · PreprintBioengineering