Mark W. Grinstaff

This paper develops a supramolecular ADC conjugation method that improves drug loading and efficacy in pancreatic cancer compared to cysteine-conjugated analogs.

This study develops and evaluates regioselectively sulfated polyamidosaccharides (disulPASs) as synthetic anticoagulants with activity similar to heparin.

This study shows that targeting lysosomal pH with rapamycin or acidic nanoparticles restores mitochondrial function in GBA1-mutant Parkinson's disease neurons.

This study presents cryo-EM structures of RXFP1 bound to relaxin-2 and AZD5462, revealing distinct activation mechanisms for protein and small-molecule agonists.

Rosindol is a new fluorogenic probe that accurately measures reactive oxygen species in living cells with linear responses and pH independence.

This study develops a modified self-amplifying RNA-based BiTE system that provides long-term B cell clearance with a single injection.

This paper develops a self-amplifying RNA platform for CAR T cells that improves durability and enables multi-genic logic functions, showing superior tumor suppression in a leukemia model.

The paper develops a nicotine biosensor using a microbial-derived redox enzyme, demonstrating detection over a clinically relevant range.

This paper introduces GRID, a high-throughput image analysis method using dispersion indices to quantify subcellular structure dynamics and spatial distributions across diverse biological contexts.

This paper develops a sulfonated interpenetrating polymer network to restore degraded cartilage ECM properties and protect against further degradation in osteoarthritis.

This paper introduces PolypCure, a hydrogel adhesive dressing that rapidly seals and hemostases colon wounds post-polypectomy, showing long-term stability and biocompatibility in an in vivo model.

This study shows that relaxin-2 reduces fibrosis and promotes regenerative healing by inhibiting TGF-b1-driven ECM deposition in both in vitro and in vivo models.

This paper develops a wearable nicotine biosensor using NicA2 and CycN, achieving high sensitivity and selectivity for real-time sweat monitoring.

This paper demonstrates that modified self-amplifying RNA (saRNA) enables long-lasting protein expression in mouse and human brain tissues.

The paper introduces RAMONA, a rapid, modular nanobody assay for antigen detection that combines portability with high sensitivity and adaptability for diverse targets.

This paper introduces a supramolecular self-assembly method for site-specific antibody conjugation using coiled-coil peptides, demonstrating improved uniformity and efficacy in targeting HER2+ tumors.

This paper introduces a framework for model-informed mRNA design using integrated gradients and an agentic hypothesis engine, achieving improved in vivo expression.

This paper develops LTGF-β conjugated scaffolds to improve neocartilage development by mimicking native TGF-β activation, achieving better mechanical and biochemical properties compared to conventional TGF-β supplementation.