Clonal expansion of mitochondrial DNA deletions is a private mechanism of ageing in long-lived animals
Lakshmi Narayanan Lakshmanan, Zhuangli Yee, Li Fang Ng, Rudiyanto Gunawan, Barry B. Halliwell, Jan Gruber
The paper identifies mtDNA deletions in ageing nematodes and finds they are rare, not age-dependent, and not clonally expanded, suggesting they are not a major driver of ageing in short-lived species.
Aging Cell · Jul 24, 2018Peer-reviewedGenetics