Lakshmi Narayanan Lakshmanan

This study benchmarks tumor-naive ctDNA detection and quantification methods using WGS and methylation data from cancer patients, identifying performance trade-offs and optimal integration strategies.

Fragle quantifies ctDNA from fragment length profiles using deep learning, showing high accuracy and improved detection limits across multiple datasets and sequencing types.

The paper identifies mtDNA deletions in ageing nematodes and finds they are rare, not age-dependent, and not clonally expanded, suggesting they are not a major driver of ageing in short-lived species.

The paper analyzes mtDNA deletion breakpoints using thermodynamic methods to identify misalignment lengths and proposes mechanisms for DSB-induced deletions.