A Hybrid Type I and II Polyketide Synthases Yields Distinct Aromatic Polyketides
Li Ya Zhao, Jing Shi, Xu Zhao, Jia Lin Sun, Zhang Yuan Yan, Zhi Wu Tong, Ren Xiang Tan, R. H. Jiao, Hui Ming Ge
The paper discovers a hybrid type I and II polyketide synthase system that produces a novel aromatic polyketide, spirocycline A, with a unique structure and biosynthetic pathway.
Journal of the American Chemical Society · Oct 16, 2024Peer-reviewedBiochemistry