Ren Xiang Tan

This paper introduces a one-pot acetylation platform for site-specific protein acetylation in E. coli and mammalian cells using novel lysine acetyltransferases.

The paper identifies novel lipopeptide biosynthetic gene clusters using bioinformatics and structural modeling, highlighting key structural features for drug development.

This study uses genetic code expansion to site-specifically lactylate proteins in living cells, revealing lactylation's impact on enzyme activity and cellular function.

The paper discovers a hybrid type I and II polyketide synthase system that produces a novel aromatic polyketide, spirocycline A, with a unique structure and biosynthetic pathway.