Jing Shi

The paper constructs a comprehensive gut microbiome reference database from Chinese and non-Chinese populations, revealing population-specific microbial features linked to host physiology.

This study determines the cryo-EM structure of the DosR-dependent transcriptional activation complex in Mtb and identifies its molecular mechanism for dormancy regulation.

This study presents cryo-EM structures of Mor-TAC and C-TAC complexes, revealing a tetrameric binding mode and interactions with RNAP, elucidating the transcription activation mechanism of phage Mor/C family activators.

This study determines cryo-EM structures of PhoP-dependent transcription complexes in Mtb to elucidate its dual role as activator and repressor in stress adaptation.

The paper discovers a hybrid type I and II polyketide synthase system that produces a novel aromatic polyketide, spirocycline A, with a unique structure and biosynthetic pathway.

The paper reports cryo-EM structures of E. coli intrinsic termination complexes to define the structural mechanism of bacterial transcription termination.