Non-canonical IL-2 signaling facilitates peripheral regulatory T cell differentiation
Amelia Meecham, Sarah Hyun Ji Kim, Mikhael Haruo Fernandes de Lima, Michelle Tang, Liao Bryan, Samuel Chan, Ho-Sup Lee, Li-fan Lu, Ziyue Zhang, Caroline Anne Jefferies, Mónica Gumá, Miguel-Alejandro Lopez-Ramirez, Mark H. Ginsberg
This study identifies MACS as a non-canonical IL-2 signaling pathway that promotes Treg differentiation and function through AP-1-dependent mechanisms.
bioRxiv · Oct 14, 2026 · PreprintImmunology