Author

Amelia Meecham

Cedars-Sinai Medical CenterORCID 0000-0003-3067-7621Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Caroline Anne JefferiesiD· 2 shared Mark H. GinsbergiD· 2 shared Aleksandr B. StotlandiD· 1 shared Arati Naveen KumariD· 1 shared Asli E. AticiiD· 1 shared Brennan KandalaftiD· 1 shared Deepika RaiiD· 1 shared Eduardo Frías-AnayaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

Caroline Anne JefferiesORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintOct 14, 2026

Non-canonical IL-2 signaling facilitates peripheral regulatory T cell differentiation

Amelia Meecham, Sarah Hyun Ji Kim, Mikhael Haruo Fernandes de Lima…·Mark H. Ginsberg

This study identifies MACS as a non-canonical IL-2 signaling pathway that promotes Treg differentiation and function through AP-1-dependent mechanisms.

DOI 10.64898/2026.10.07.756301

mousebulk RNA-seq

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ImmunologybioRxivPreprintSep 15, 2025

Mitochondrial instability contributes to IFN-driven heart disease.

Arati Naveen Kumar, Amelia Meecham, Deepika Rai…·Caroline Anne Jefferies

This study shows chronic IFN exposure impairs heart function by causing mitochondrial stress, mtDNA release, and a self-sustaining inflammatory loop in cardiomyocytes.

DOI 10.1101/2025.09.15.674036

mousehuman

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PathologyInternational Journal of Molecular SciencesPeer-reviewedMay 2, 2025

Silencing KRIT1 Partially Reverses the Effects of Disturbed Flow onThe Endothelial Cell Transcriptome

Amelia Meecham, Sara McCurdy, Eduardo Frías-Anaya…·Miguel Alejandro Lopez‐Ramirez

This study shows that silencing KRIT1 in endothelial cells under disturbed flow restores KLF2 and KLF4 expression, mimicking the transcriptomic profile of cells under laminar flow.

3 citations

humanbulk RNA-seq

𝕏 PostBluesky