Caroline Anne Jefferies

Non-canonical IL-2 signaling facilitates peripheral regulatory T cell differentiation

This study identifies MACS as a non-canonical IL-2 signaling pathway that promotes Treg differentiation and function through AP-1-dependent mechanisms.

Mitochondrial instability contributes to IFN-driven heart disease.

This study shows chronic IFN exposure impairs heart function by causing mitochondrial stress, mtDNA release, and a self-sustaining inflammatory loop in cardiomyocytes.

Loss of TRIM21 drives UVB-induced systemic inflammation by regulating DNA-sensing pathways

This study shows that loss of TRIM21 increases UVB-induced systemic inflammation by enhancing IFN expression through impaired STING signaling in mice.

Alterations in genes associated with cytosolic RNA sensing in whole blood are associated with coronary microvascular disease in SLE

The paper identifies gene signatures and pathways associated with coronary microvascular disease in SLE patients through RNA-seq and pathway analysis.

High-throughput mRNA-seq atlas of human placenta shows vast transcriptome remodeling from first to third trimester

The paper constructs an mRNA-seq atlas of human placenta across gestation, identifying extensive transcriptome changes from first to third trimester.

Sex differences in microRNA expression in first and third trimester human placenta

The paper identifies sex differences in miRNA expression in first and third trimester human placenta, finding more pronounced dimorphism in the first trimester with twice as many female-specific differences.

High-throughput miRNA-sequencing of the human placenta: expression throughout gestation

This study uses high-throughput miRNA-sequencing to analyze miRNA expression in first and third trimester human placentae, identifying differentially expressed and stable miRNAs across gestation.