Co-repression of Yap1 and Sox9 Abrogates Established Cholangiocarcinoma by Eliminating Transcriptional Compensation
Minwook Kim, Shikai Hu, Yoojeong Park, Joseph Kwon, Laura Maria Molina, Li-Ju Wang, Jia-Jun Liu, Silvia Liu, Aatur Singhi, Yu‐Chiao Chiu, Sungjin Ko
This study shows that deleting both Sox9 and Yap1 eliminates cholangiocarcinoma by blocking transcriptional compensation, suggesting co-targeting as a therapeutic strategy.
Clinical and Molecular Hepatology · Apr 3, 2026Peer-reviewedCancer Biology