Author

Shikai Hu

University of PittsburghORCID 0000-0002-0817-991XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Minwook KimiD· 2 shared Silvia LiuiD· 2 shared Sungjin KoiD· 2 shared Yoojeong ParkiD· 2 shared Aatur Dilip SinghiiD· 1 shared Aatur Singhi· 1 shared Jia-Jun LiuiD· 1 shared Joseph KwoniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCancer Biology

Minwook KimORCID

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2 papers

Recent·Most cited

Cancer BiologyClinical and Molecular HepatologyPeer-reviewedApr 3, 2026

Co-repression of Yap1 and Sox9 Abrogates Established Cholangiocarcinoma by Eliminating Transcriptional Compensation

Minwook Kim, Shikai Hu, Yoojeong Park…·Sungjin Ko

This study shows that deleting both Sox9 and Yap1 eliminates cholangiocarcinoma by blocking transcriptional compensation, suggesting co-targeting as a therapeutic strategy.

DOI 10.3350/cmh.2025.1170

mousebulk RNA-seq

𝕏 PostBluesky

Cancer BiologyCellsPeer-reviewedAug 29, 2024

Therapeutic potential of SOX9 dysruption in Combined Hepatocellular Carcinoma-Cholangiocarcinoma

Yoojeong Park, Shikai Hu, Minwook Kim…·Sungjin Ko

This study contrasts the effects of developmental and acute Sox9 deletion in cHCC-CCA models, showing that Sox9 elimination can reduce tumor burden and highlights therapeutic potential.

4 citations

mousegenetic perturbation / CRISPR

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