Minwook Kim

Co-repression of Yap1 and Sox9 Abrogates Established Cholangiocarcinoma by Eliminating Transcriptional Compensation

This study shows that deleting both Sox9 and Yap1 eliminates cholangiocarcinoma by blocking transcriptional compensation, suggesting co-targeting as a therapeutic strategy.

SALL4 is required for YAP1-dependent malignant and regenerative hepatocyte reprogramming into cholangiocyte lineage

This study identifies SALL4 as a regulator of YAP1-driven hepatocyte-to-cholangiocyte reprogramming, showing its role in both malignant and regenerative liver processes.

Therapeutic potential of SOX9 dysruption in Combined Hepatocellular Carcinoma-Cholangiocarcinoma

This study contrasts the effects of developmental and acute Sox9 deletion in cHCC-CCA models, showing that Sox9 elimination can reduce tumor burden and highlights therapeutic potential.

Developmental Reactive Oxygen Species Target Histone Methylation to Individualize Stress resistance and Lifespan

The paper shows that early developmental ROS increases stress resistance and lifespan by reducing histone H3K4me3 levels in C. elegans and mammalian cells.