Gut bacteria generate prodrugs in situ increasing systemic drug exposure
Ting-Hao Kuo, Anoop Singh, Amber Brauer-Nikonow, Mahnoor Zulfiqar, Resul Gökberk Elgin, Li-Yao Chen, Matthias Gross, George Maftei, Michael Zimmermann
The paper identifies gut bacteria that convert drugs into prodrugs, increasing systemic drug exposure and altering pharmacokinetics.
bioRxiv · Dec 9, 2025 · PreprintMicrobiology