Molecular BiologyMolecular and Cellular BiologyPeer-reviewed
Ectopic methylation of a single persistently-unmethylated CpG in the promoter of the vitellogenin gene abolishes its inducibility by estrogen through attenuation of USF binding.
Lia Kallenberger, Rachel Erb, Lucie Kralickova…·Josef Jiricny
The paper shows that methylation of a single CpG in an E-box upstream of the VTG TATA box blocks USF binding and estrogen-induced transcription.