Author

Josef Jiricny

University of ZurichORCID 0000-0002-1831-8186Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Amandine MorettoniD· 1 shared Andrea PatrignaniiD· 1 shared Barbara van LooniD· 1 shared Ching Chiek KohiD· 1 shared Christian HeinisiD· 1 shared Christian‐Benedikt GerholdiD· 1 shared Chrysanthi KagiouiD· 1 shared Cleo V D Tarashev· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperMolecular Biology

Amandine MorettonORCID

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4 papers

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedFeb 9, 2022

Prime Editing Efficiency and Fidelity are Enhanced in the Absence of Mismatch Repair

Joana Ferreira da Silva, Gonçalo P. Oliveira, Emili A. Arasa-Verge…·Joanna I. Loizou

This study shows that removing mismatch repair factors increases prime editing efficiency across multiple cell lines and edits.

183 citationstop 1%

humanexperimental assay

𝕏 PostBluesky

Molecular BiologybioRxivPreprintNov 15, 2020

Uncoordinated long-patch base excision repair at juxtaposed DNA lesions generates a lethal accumulation of double-strand breaks

Kenji Shimada, Barbara van Loon, Christian‐Benedikt Gerhold…·Susan M. Gasser

The paper shows that uncoordinated BER activity at DNA lesions causes DSB accumulation in yeast exposed to Zeocin, leading to genomic fragmentation.

3 citations

yeastDNA methylation

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GenomicsNature CommunicationsPeer-reviewedApr 24, 2020

Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts

Ilias Georgakopoulos‐Soares, Ching Chiek Koh, Sophie Momen…·Serena Nik‐Zainal

The paper analyzes indel distribution relative to transcription to show strand asymmetry and links it to DNA repair mechanisms in human cancers.

28 citations

humanwhole-genome sequencing

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Molecular BiologyMolecular and Cellular BiologyPeer-reviewedSep 19, 2019

Ectopic methylation of a single persistently-unmethylated CpG in the promoter of the vitellogenin gene abolishes its inducibility by estrogen through attenuation of USF binding.

Lia Kallenberger, Rachel Erb, Lucie Kralickova…·Josef Jiricny

The paper shows that methylation of a single CpG in an E-box upstream of the VTG TATA box blocks USF binding and estrogen-induced transcription.

4 citations

DNA methylationexperimental assay

𝕏 PostBluesky