Tuning the open-close equilibrium of Cereblon with small molecules influences protein degradation
Suzanne O’Connor, Zoe J. Rutter, Angus D. Cowan, Markus Zeeb, Florian P. C. Binder, Yuting Cao, Sohini Chakraborti, Stefan Djukic, Leonhard Geist, Elizabeth K. J. Hogg, Giorgia Kidd, Matthias Krumb, Simon Langer, Denis Schmidt, Liam Martin, , Alessio Ciulli
This study identifies CRBN binders that induce or fail to induce CRBN closure, showing that closure is critical for degrader activity.
bioRxiv · Dec 22, 2025 · PreprintBiochemistry