Author

Angus D. Cowan

University of DundeeORCID 0000-0002-9702-7319Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Alessio CiulliiD· 3 shared Alejandro Correa-SáeziD· 1 shared Caroline SchätziD· 1 shared Denis SchmidtiD· 1 shared Dmitri SegaliD· 1 shared Elisha H. McCroryiD· 1 shared Elizabeth K. J. HoggiD· 1 shared Florian P. C. BinderiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

Alessio CiulliORCID

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3 papers

Recent·Most cited

Scalable insect cell expression and purification screening applied to CRL4-DCAF substrate receptors

Angus D. Cowan, Sarah Jaekel, Alessio Ciulli

The paper describes a high-throughput screening method for expressing and purifying DCAF proteins in insect cells, identifying 8 previously unexpressed DCAFs as promising candidates for further study.

Protein Expression and Purification · Mar 4, 2026Peer-reviewedMolecular Biology

Tuning the open-close equilibrium of Cereblon with small molecules influences protein degradation

Suzanne O’Connor, Zoe J. Rutter, Angus D. Cowan, Markus Zeeb, Florian P. C. Binder, Yuting Cao, Sohini Chakraborti, Stefan Djukic, Leonhard Geist, Elizabeth K. J. Hogg, Giorgia Kidd, Matthias Krumb, Simon Langer, Denis Schmidt, Liam Martin, , Alessio Ciulli

This study identifies CRBN binders that induce or fail to induce CRBN closure, showing that closure is critical for degrader activity.

bioRxiv · Dec 22, 2025 · PreprintBiochemistry

Dual E3 ligase recruitment by monovalent degraders enables redundant and tuneable degradation of SMARCA2/4

Valentina A. Spiteri, Dmitri Segal, Alejandro Correa-Sáez, Kentaro Iso, Ryan Casement, Miquel Muñoz i Ordoño, Mark A. Nakasone, Gajanan J. Sathe, Caroline Schätz, Hannah E. Peters, Mark Dorward, Lisa Kainacher, Angus D. Cowan, Alessio Ciulli, Georg E. Winter

This study shows that a monovalent MGD can recruit two E3 ligases redundantly to degrade SMARCA2/4, with tunable ligase preference through chemical and genetic modifications.

bioRxiv · Aug 4, 2025 · PreprintBiochemistry